Journal: Theranostics
Article Title: Pattern recognition of microcirculation with super-resolution ultrasound imaging provides markers for early tumor response to anti-angiogenic therapy
doi: 10.7150/thno.89306
Figure Lengend Snippet: Progressive response of tumor microvascular heterogeneity to anti-angiogenic therapy. (A-B) Representative three-dimensional (3D) morphological and functional maps of tumor microvasculature from typical bevacizumab (B) and PBS-treated tumors (A) during treatment. The 3D microvasculature is shown as a 2D maximum-intensity projection. Corresponding density distribution in the pattern recognition of microcirculation (PARM)-reconstructed functional feature space is demonstrated accordingly, with 2D projection shown above the 3D density plots. The speed values were normalized for demonstration. (C, D) The longitudinal changes of PARM-derived heterogeneity parameters and pathological indicators. Differences in parameters during treatment were determined by two-way ANOVA with Bonferroni correction (* = P < 0.05, ** = P < 0.01). White scale bar: 1 mm.
Article Snippet: The clinically used antiangiogenic agent bevacizumab (MedChemExpress, NJ, USA, #HY-P9906) was diluted in phosphate-buffered saline (PBS, pH 7.4, Hyclone, USA), and was administered every other day for 12 days ( ) via intraperitoneal injection at a dose of 10 mg/kg for animals in the treatment group.
Techniques: Functional Assay, Derivative Assay